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1 subjected 9-week-old and 69-week-old C57BL/6J mice to cigarette smoke and found that the older animals had a greater neutrophil influx in the lungs, higher levels of the neutrophil chemo-attractants MIP-2 and keratinocyte-derived chemokine in bronchoalveolar lavage fluid, and greater nuclear translocation of NF-B in bronchiolar epithelium